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Rose was helped off the court. He had 23 points, nine rebounds and nine assists when he was injured.
The Bulls won 103-91, and Game 2 is Tuesday, giving Rose a couple of extra days to rest.
"I hope he's not seriously hurt," 76ers coach Doug Collins said. "I admire him so much. I think he's one of the young, bright lights in this NBA. And I hope he's going to be back and he's going to be able to play, because I admire greatness, and he's a great player."
The 23-year-old Rose played in just 39 of the Bulls' 66 regular-season games because of an assortment of injuries, including turf toe, back spasms, pulled groin and foot injury. He hasn't played more than two games in a row since suffering a foot injury March 12.